Products & Services
Princeton BioMolecular Research is an experienced and reliable source of compounds for major pharmaceutical and agricultural companies. Our compound libraries are designed to possess drug-like properties. They are created using innovative technologies along with traditional medicinal chemistry principles. Mixing these technologies have streamlined an efficient synthesis while yielding highly pure compounds. Our technologies efficiently synthesize unique and highly pure compounds, while allowing rapid follow-up synthesis for lead development.
The Natural Collection is a Library containing more than 45,000 compounds.
The variety of known biologically active compounds of natural origin is very wide. The potential of the natural plant collection includes approximately 30 million of compounds. Even combinatorial chemistry, an effective instrument in selection of leading structures can’t compete with the variety of biologically active natural compounds.
Synthetic preparations, modeling active natural compounds and being their chemical analogs, attract growing interest among the pharmacologists, physiologists, bio-chemists, who try to widen the list of medicinal preparations.
The Express Collection is a Stock Library offering over 700,000 compounds with more than 50 chemical classes represented.
Stock Libraries are re-evaluated quarterly with new stock being added and unavailable compounds being eliminated. With 90+% purity and delivery with 3-5 days your High Throughput Screening output can be fast and efficient. The distribution of molecular weight, number of hydrogen bond donors, number of hydrogen bond acceptors, and logP values are consistent with the drug-like character.
Virtual Library consists of over 1,000,000 compounds made to order. Any compound ordered from this library can be synthesized and delivered in 1-2 months.
The total number of compounds in our library sets consists of more than 1.4 million chemical structures and continues to grow with quality structure additions.
Scaffold Collection - is a library containing more than 2000 motifs.
While virtual DB is a valuable source for the customers interested in the new, non-existing compounds it has its shortcomings: the DB is very big in size for the web distribution, deliverability is on a low side - around 50% and it can be somewhat expensive.
In order to overcome these we introducing new concept - similar but better. It's called Scaffold Program. Our customers select scaffold (fragment) based on their filter criteria and then we create a library containing all possible structural combinations. Then our group of chemists checks every single structure to identify what can be synthesized and present a virtual DB that has much higher rate of success - up to 90% and is more attractive to particular customer since it's based on a fragment(s) selected by client.
Currently our collection covers diverse chemical and pharmacophoric space. Typically, to have a good coverage and retain optimal chemical diversity, the size of a set for each selected scaffold varies from 100 to 700 compounds. We prepare these sets on scale, up to 100mg and at the designated purity.
Compounds can be offered on exclusive or non-exclusive bases.
Our building block collection includes 35,000 versatile reagents for diversification. The building block collection contains amines, protected amino acids, carboxylic acids, acid halides, mono-protected diamines, aldehydes, phenols as well as unique heterocyclic compounds and common pharmacophores. The majority of our compounds are novel and not available through other commercial sources.
We offer a wide variety of unique Focused Library sets targeting Kinases, GPCRs and some other enzymes. There are also Focused Libraries targeting specific sub-families of biological targets. Thus our Kinase Library contains over a dozen subsets of compounds with specific kinase activity and our GPCR Library similarly has ten subsets of compounds.
To assemble a set of compounds with particular biological activity we carefully selected known pharmacophores and novel inhibitors from the recent patents, literature and available databases. This information was further filtered with our proprietary computational methods, as well as PSA, ClogP, Tanimoto similarity and other predictions. Each set contains between 300 and 1000 compounds in amounts from 1mg to 5mg in the clients desired form; vials, plates, dry form, or dissolved in DMSO. General purity levels are 90%-95%.
Lead-time for delivery can be short as two weeks, depending on the number of samples that have been selected.
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Kinase Sets |
Miscellaneous Enzyme Sets |
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PKA |
Farnesyl Transferase |
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GPCR Sets |
Channel Blocker Sets |
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Endothelin Receptor Antagonists |
Ca Channel Blocker |
Custom Synthesis & Contract Research
Princeton BioMolecular Research can provide the synthesis of compounds within a particular class of molecules selected by the customer. We have chemical synthesis expertise in a wide range drug discovery fields and can offer the production of compounds with exclusive or non-exclusive agreements up to 100 grams. We also offer derivatization of various heterocyclic compounds, pharmacophores and small molecules.
Liquid Handling & Weighing Services
Princeton BioMolecular Research performs custom weighing and custom plating of samples. We are equipped for DMSO additions and 96 to 384 well transfers. Samples can be weighed into micro tube plates, block plates and glass vials. We can supplement your in-house sample handling by making mother plates, daughter plates and 384 well versions of your compounds. PBMR can take your entire collection and move it into a new format, for example, dissolving compounds in DMSO to make new mother plates.
Quality Assurance
We consider quality of all our compounds as a crucial issue. To insure customer satisfaction, all our compounds are accompanied with 1H NMR and /or LC/MS trace and Mass Spectra to verify purity. The purity for our compound collection is +90% and building blocks +97%. Our highly qualified staff can solve a wide range of complicated research problems on structure determination of organic, organometallic and bioorganic compounds. The structure elucidation can be further complimented by high-resolution NMR nuclei techniques, for example, N - 14, F - 19, B -11, N - 15, Si - 29 and many more. A computer based network system developed in our laboratory allows us to run over 25,000 routine spectra monthly on a 300-500 MHz NMR. All the spectrometers are equipped with personal computers, laser printers and barcode readers for efficiency.
Princeton BioMolecular Research provides analytical support and quality control for all plated compounds. It includes several HPLC equipped with UV detection or LSD (Light Scattering Detector) detection and an optional MS detection. All data is available in electronic form or as a hard copy. In all cases, chemical structures can be inserted into the spectra if the customer provides us with SDFile (or database) for the set of compounds.
