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Princeton BioMolecular Research is an experienced and reliable source of compounds for major pharmaceutical and agricultural companies. Our compound libraries are designed to possess drug-like properties. They are created using innovative technologies along with traditional medicinal chemistry principles. Mixing these technologies have streamlined an efficient synthesis while yielding highly pure compounds. Our technologies efficiently synthesize and highly pure compounds, while allowing rapid follow-up synthesis for lead development
Focused Libraries
We offer a wide variety of unique Focused Library sets targeting Kinases, GPCRs and some other enzymes. There are also Focused Libraries targeting specific sub-families of biological targets. Thus our Kinase Library contains over a dozen subsets of compounds with specific kinase activity and our GPCR Library similarly has ten subsets of compounds.
To assemble a set of compounds with particular biological activity we carefully selected known pharmacophores and novel inhibitors from the recent patents, literature and available databases. This information was further filtered with our proprietary computational methods, as well as PSA, ClogP, Tanimoto similarity and other predictions. Each set contains between 300 and 1000 compounds in amounts from 1mg to 5mg in the clients desired form; vials, plates, dry form, or dissolved in DMSO. General purity levels are 90%-95%.
Lead-time for delivery can be short as two weeks, depending on the number of samples that have been selected.
Kinase Sets |
Miscellaneous Enzyme Sets |
PKA
PKC
Tyrosine
Thymidine
CDK
MEK
MAP
Adenosine
Casein
Calmoduline
JUN
GS
MLC
P38 |
Farnesyl Transferase
PDE I
PDE II
PDE III
PDE IV
PDE V
Factor Xa Inhibitor
ACE
Reverse Transcriptase
Thrombin
Cyclooxygenase-2 |
GPCR Sets |
Channel Blocker Sets |
Endothelin Receptor Antagonists
GHS1a Antagonists
NK2 Antagonists
5HT1 Antagonists
5HT2 Antagonists
5HT3 Antagonists
5HT4 Antagonists
5HT1 Agonists
5HT3 Agonists
5HT4 Agonists
Dopamine Antagonists
CCR2 Antagonists
CCR5 Antagonists
CRF1 Antagonists
Sst Antagonists
Angiotensin II Receptor Antagonists
Bradykinin BK2 Antagonist
Histamine H3 Antagonist |
Ca Channel Blocker
Na Channel Blocker
K Channel Blocker
Ion Channel Blocker |
Lead Generation Libraries
We offer collections of Drug-relevant, Synthetic Small Molecules, Natural Extracts & Derivatives.
The Platinum Collection is a Stock Library contains 27,000 compounds exclusive to Princeton BioMolecular Research.
The Gold Collection is a Stock Library offering over 500,000 compounds with more than 50 chemical classes represented.
Both Stock Libraries are re-evaluated quarterly with new stock being added and unavailable compounds being eliminated. With 90+% purity and delivery with 3-5 days your High Throughput Screening output can be fast and efficient. The distribution of molecular weight, number of hydrogen bond donors, number of hydrogen bond acceptors, and logP values are consistent with the drug-like character.
Our Virtual Library consists of over 1,000,000 compounds made to order. Any compound ordered from this library can be synthesized and delivered in 1-2 months.
The total number of compounds in our library sets consists of more than 1.4 million chemical structures and continues to grow with quality structure additions.
Lead Optimization Libraries
We also can build a Lead Optimization library based on your scaffolds, suggested synthetic approaches or your original hits.
Custom Libraries
We offer exclusive / non - exclusive synthesis of novel screening compounds - Custom Library, based on pre-selected scaffolds/pharmacophores. For Custom Library we offer an existing collection of over 700 synthetic and 250 natural scaffolds, which cover diverse chemical and pharmacophoric space. Typically, to have a good coverage of chemical space while retaining optimal chemical diversity, the size of a set for each selected scaffold varies from 200 to 500 compounds. We prepare these sets on scale, up to 100 mg and the designated purity. Working together with your specifications and our chemical expertise, we can build a scaffold library to meet your target needs.
Custom Synthesis & Contract Research
Princeton BioMolecular Research can provide the synthesis of compounds within a particular class of molecules selected by the customer. We have chemical synthesis expertise in a wide range drug discovery fields and can offer the production of compounds with exclusive or non-exclusive agreements up to 100 grams. We also offer derivatization of various heterocyclic compounds, pharmacophores and small molecules.
Building Blocks
Our building block collection includes 5,000 versatile reagents for diversification. The building block collection contains amines, protected amino acids, carboxylic acids, acid halides, mono-protected diamines, aldehydes, phenols as well as unique heterocyclic compounds and common pharmacophores. The majority of our compounds are novel and not available through other commercial sources.
Liquid Handling & Weighing Services
Princeton BioMolecular Research performs custom weighing and custom plating of samples. We are equipped for DMSO additions and 96 to 384 well transfers. Samples can be weighed into micro tube plates, block plates and glass vials. We can supplement your in-house sample handling by making mother plates, daughter plates and 384 well versions of your compounds. PBMR can take your entire collection and move it into a new format, for example, dissolving compounds in DMSO to make new mother plates.
Quality Assurance
We consider quality of all our compounds as a crucial issue. To insure customer satisfaction, all our compounds are accompanied with 1H NMR and /or LC/MS trace and Mass Spectra to verify purity. The purity for our compound collection is +90% and building blocks +97%. Our highly qualified staff can solve a wide range of complicated research problems on structure determination of organic, organometallic and bioorganic compounds. The structure elucidation can be further complimented by high-resolution NMR nuclei techniques, for example, N - 14, F - 19, B -11, N - 15, Si - 29 and many more. A computer based network system developed in our laboratory allows us to run over 25,000 routine spectra monthly on a 300-500 MHz NMR. All the spectrometers are equipped with personal computers, laser printers and barcode readers for efficiency.
Princeton BioMolecular Research provides analytical support and quality control for all plated compounds. It includes several HPLC equipped with UV detection or LSD (Light Scattering Detector) detection and an optional MS detection. All data is available in electronic form or as a hard copy. In all cases, chemical structures can be inserted into the spectra if the customer provides us with SDFile (or database) for the set of compounds.
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